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Anti-Human B4GALNT2 Polyclonal Antibody (HP667014)

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Overview
Catalog No.HP667014
Description
Anti-Human B4GALNT2 Polyclonal Antibody (HP667014) is a rabbit polyclonal antibody detecting B4GALNT2. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human B4GALNT2 (Thr324-Ala566).
Target B4GALNT2, Beta-1,4 N-acetylgalactosaminyltransferase 2, EC:2.4.1.-, GALGT2, Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8NHY0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2) is a ~63 kDa protein. Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells.

1. Montiel, MD. et al. (2003) The Biochemical journal 373, 369-79. PMID: 12678917
2. Lo Presti, L. et al. (2003) Journal of biochemistry 134, 675-82. PMID: 14688233
3. Kawamura, YI. et al. (2005) Cancer research 65, 6220-7. PMID: 16024623
4. Stenfelt, L. et al. (2022) International journal of molecular sciences 23. PMID: 35409292
5. Heaton, BE. et al. (2017) Cell reports 20, 1503-1512. PMID: 28813663
Note For research use only
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Formula
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Anti-Human B4GALNT2 Polyclonal Antibody

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