Anti-Human CBX1 Polyclonal Antibody (HX177014)

Name: Anti-Human CBX1 Polyclonal Antibody
Brand: abinScience
SKU: HX177014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX177014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human CBX1 (Glu24-Leu168).

Target

HP1Hsbeta, CBX, Chromobox protein homolog 1, Modifier 1 protein, Heterochromatin protein 1 homolog beta, HP1 beta, M31, CBX1, p25beta, Heterochromatin protein p25

Purification

Purified by antigen affinity column.

Accession

P83916

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Chromobox protein homolog 1 (CBX1) is a ~21 kDa protein. Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

1. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177

Note

For research use only.

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References

Datasheet