Anti-Human CBX3 Recombinant Antibody (SAA2131) (HC291033)

Name: Anti-Human CBX3 Recombinant Antibody (SAA2131)
Brand: abinScience
SKU: HC291033
Price: 191 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC291033

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a

Clone ID

SAA2131

Clonality

Monoclonal

Target

CBX3, Chromobox protein homolog 3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13185

RRID

Anti-Human CBX3 Antibody (SAA2131) (abinScience Cat# HC291033, RRID:AB_3729484)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Chromobox protein homolog 3 (CBX3) is a ~20 kDa protein. Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

1. Lachner, M. et al. (2001) Nature 410, 116-20. PMID: 11242053

2. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177

3. Obuse, C. et al. (2004) Nature cell biology 6, 1135-41. PMID: 15502821

4. Bot, C. et al. (2017) Journal of cell science 130, 1134-1146. PMID: 28167679

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CBX3 Antibody (SAA2131)

References

Datasheet

Anti-Human CBX3 Recombinant Antibody (SAA2131).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CBX3 Recombinant Antibody (SAA2131) (HC291033)

Overview

Images

References

Datasheet

SDS

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