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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4), PE (HB791227)

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Overview

Catalog No.	HB791227
Description	Anti-Human CD121a/IL1R1 Antibody (15C4), PE [15C4] (HB791227) is a mouse monoclonal antibody detecting CD121a in ELISA, FCM, IF, WB. Suitable for Human and Monkey. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human, Monkey
Applications	ELISA, FCM, IF, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	15C4
Conjugation	PE
Clonality	Monoclonal
Target	IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80
Endotoxin level	Please contact with the lab for this information.
Accession	P14778
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4), PE.pdf

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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4), PE