Anti-Human Fas Ligand/TNFSF6 Recombinant Antibody (NOK2/NOK-2) (HW497107)

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Overview

Catalog No.	HW497107
Description	Anti-Human CD178/FASLG/TNFSF6 Antibody (NOK2/NOK-2) [NOK2/NOK-2] (HW497107) is a mouse monoclonal antibody detecting TNFSF6 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	NOK2/NOK-2
Clonality	Monoclonal
Target	Receptor-binding FasL ectodomain, APL, APT1LG1, FasL ICD, Fas antigen ligand, CD178, sFasL, CD95L, APTL, TNFSF6, Apoptosis antigen ligand, SPA, FASLG, FasL, SPPL2A-processed FasL form, Tumor necrosis factor ligand superfamily member 6, Soluble Fas ligand, Fas ligand, CD95 ligand, CD95-L, FASL
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P48023
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Tumor necrosis factor ligand superfamily member 6 (CD178/FASLG) is a ~31 kDa protein. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. 1. Ruiz-García, R. et al. (2015) Pediatric research 78, 603-8. PMID: 26334989 2. Schneider, P. et al. (1997) The Journal of biological chemistry 272, 18827-33. PMID: 9228058 3. Alderson, MR. et al. (1995) The Journal of experimental medicine 181, 71-7. PMID: 7528780 4. Tanaka, M. et al. (1998) Nature medicine 4, 31-6. PMID: 9427603 5. Liu, W. et al. (2016) Structure (London, England : 1993) 24, 2016-2023. PMID: 27806260
Note	For research use only.

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SEC-HPLC detection for Anti-Human CD178/FASLG/TNFSF6 Antibody (NOK2/NOK-2).

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Anti-Human Fas Ligand/TNFSF6 Recombinant Antibody (NOK2/NOK-2).pdf

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Anti-Human Fas Ligand/TNFSF6 Recombinant Antibody (NOK2/NOK-2) (HW497107)

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