Protein A/G purified from cell culture supernatant.
Accession
P48023
Form
Liquid
Storage buffer
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names
APG-101, 1450882-18-4
Background
Tumor necrosis factor ligand superfamily member 6 (CD178/FASLG) is a ~31 kDa protein. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
1. Ruiz-García, R. et al. (2015) Pediatric research 78, 603-8. PMID: 26334989
2. Schneider, P. et al. (1997) The Journal of biological chemistry 272, 18827-33. PMID: 9228058
3. Alderson, MR. et al. (1995) The Journal of experimental medicine 181, 71-7. PMID: 7528780
4. Tanaka, M. et al. (1998) Nature medicine 4, 31-6. PMID: 9427603
5. Liu, W. et al. (2016) Structure (London, England : 1993) 24, 2016-2023. PMID: 27806260
Note
For research use only. Not suitable for clinical or therapeutic use.
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