Anti-Human CD218a/IL18R1 Recombinant Antibody (1G12) (HC691107)

Name: Anti-Human CD218a/IL18R1 Recombinant Antibody (1G12)
Brand: abinScience
SKU: HC691107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HC691107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	1G12
Clonality	Monoclonal
Target	CD218a, IL-18R1, IL18R1, CDw218a, IL-18R-alpha, IL-18R-1, Interleukin-18 receptor 1, IL-18Ralpha, IL1 receptor-related protein, CD218 antigen-like family member A, IL-1Rrp, IL1RRP, IL1R-rp, Interleukin-18 receptor alpha
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13478
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-18 receptor 1 (CD218a/IL18R1) is a ~62 kDa protein. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. 1. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 2. Wei, H. et al. (2014) FEBS letters 588, 3838-43. PMID: 25261253 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Parnet, P. et al. (1996) The Journal of biological chemistry 271, 3967-70. PMID: 8626725 6. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For research use only.

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Bioactivity

Detects CD218a/IL18R1 in indirect ELISAs.

References

Datasheet

Anti-Human CD218a/IL18R1 Recombinant Antibody (1G12).pdf

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Recombinant Proteins

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Anti-Human CD218a/IL18R1 Recombinant Antibody (1G12) (HC691107)

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