Anti-Human BCAM Recombinant Antibody (C7#), APC (HW406137)

Name: Anti-Human BCAM Recombinant Antibody (C7#), APC
Brand: abinScience
SKU: HW406137
Price: 290 USD
Availability: InStock

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Catalog No.	HW406137
Description	Anti-Human BCAM Recombinant Antibody (C7#), APC (HW406137) is a mouse monoclonal antibody detecting BCAM in FCM. Suitable for Human. Highlights ●APC Conjugated — Ready for direct detection without secondary antibody.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG1, kappa
Clone ID	C7#
Conjugation	APC
Target	Basal cell adhesion molecule, LU, MSK19, Auberger B antigen, CD239, Lutheran blood group glycoprotein, Lutheran antigen, F8/G253 antigen, B-CAM cell surface glycoprotein, BCAM
Endotoxin level	< 10 EU/mg
Purity	>90% as determined by SDS-PAGE.
Associated products	Mouse IgG1 kappa Recombinant Isotype Control Antibody (MOPC-21), APC
Accession	P50895
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Basal cell adhesion molecule (CD239/BCAM) is a ~67 kDa protein. Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. 1. Udani, M. et al. (1998) The Journal of clinical investigation 101, 2550-8. PMID: 9616226 2. Guadall, A. et al. (2019) The Journal of biological chemistry 294, 14911-14921. PMID: 31413112 3. El Nemer, W. et al. (2007) Blood 109, 3544-51. PMID: 17158232 4. Gauthier, E. et al. (2005) The Journal of biological chemistry 280, 30055-62. PMID: 15975931 5. De Grandis, M. et al. (2013) Blood 121, 658-65. PMID: 23160466
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human BCAM Recombinant Antibody (C7#), APC.pdf

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Anti-Human BCAM Recombinant Antibody (C7#), APC (HW406137)

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