Anti-Human CD239/BCAM Recombinant Antibody (C7#) (HW406107)

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Overview

Catalog No.

HW406107

Description

Anti-Human CD239/BCAM Antibody (C7#) [C7#] (HW406107) is a mouse monoclonal antibody detecting CD239 in FCM, WB. Suitable for Human.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Species reactivity

Human

Applications

FCM, WB

Host species

Mouse

Isotype

IgG1, kappa

Clone ID

C7#

Clonality

Monoclonal

Target

Basal cell adhesion molecule, LU, MSK19, Auberger B antigen, CD239, Lutheran blood group glycoprotein, Lutheran antigen, F8/G253 antigen, B-CAM cell surface glycoprotein, BCAM

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P50895

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Basal cell adhesion molecule (CD239/BCAM) is a ~67 kDa protein. Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.

1. Udani, M. et al. (1998) The Journal of clinical investigation 101, 2550-8. PMID: 9616226

2. Guadall, A. et al. (2019) The Journal of biological chemistry 294, 14911-14921. PMID: 31413112

3. El Nemer, W. et al. (2007) Blood 109, 3544-51. PMID: 17158232

4. Gauthier, E. et al. (2005) The Journal of biological chemistry 280, 30055-62. PMID: 15975931

5. De Grandis, M. et al. (2013) Blood 121, 658-65. PMID: 23160466

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD239/BCAM Antibody (C7#)

References

Datasheet

Anti-Human CD239/BCAM Recombinant Antibody (C7#).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CD239/BCAM Recombinant Antibody (C7#) (HW406107)

Overview

Images

References

Datasheet

SDS

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