

| Catalog No. | HC421014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human CD242/ICAM4 Polyclonal Antibody (HC421014) is a rabbit polyclonal antibody detecting CD242. Suitable for Human.
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human CD242/ICAM4 (Met52-Trp234). | ||||||||
| Target | CD242, ICAM-4, ICAM4, Intercellular adhesion molecule 4, LW, LW blood group protein, Landsteiner-Wiener blood group glycoprotein | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q14773 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Background | Intercellular adhesion molecule 4 (CD242/ICAM4) is a ~29 kDa protein. Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis. Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes. 1. Ihanus, E. et al. (2007) Blood 109, 802-10. PMID: 16985175 2. Hermand, P. et al. (2003) The Journal of biological chemistry 278, 4892-8. PMID: 12477717 3. Hermand, P. et al. (2004) European journal of biochemistry 271, 3729-40. PMID: 15355350 4. Hermand, P. et al. (2000) The Journal of biological chemistry 275, 26002-10. PMID: 10846180 5. Spring, FA. et al. (2001) Blood 98, 458-66. PMID: 11435317 | ||||||||
| Note | For research use only |
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