Anti-Human CD340/ERBB2/HER2/NEU Recombinant Antibody (A21) (HY286307)

Name: Anti-Human CD340/ERBB2/HER2/NEU Recombinant Antibody (A21)
Brand: abinScience
SKU: HY286307
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HY286307
Species reactivity	Human
Applications	ELISA, FCM, IHC, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	A21
Clonality	Monoclonal
Target	p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04626
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu).
Note	For research use only.

Images

Flow-cytometry

Flow-cytometry using anti-human ERBB2 antibody.MCF7 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB2 antibody monoclonal antibody (Catalog # HY286307 ,Green Histogram) at a concentration of 5 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow-cytometry

Flow-cytometry using anti-human ERBB2 antibody.MDA-MB-231 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB2 antibody monoclonal antibody (Catalog # HY286307 ,Green Histogram) at a concentration of 5 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow-cytometry

Flow-cytometry using anti-human ERBB2 antibody.MDA-MB-231 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB2 antibody monoclonal antibody (Catalog # HY286307 ,Green Histogram) at a concentration of 5 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow-cytometry

Flow-cytometry using anti-human ERBB2 antibody.SK-BR-3 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB2 antibody monoclonal antibody (Catalog # HY286307 ,Green Histogram) at a concentration of 5 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human CD340/ERBB2/HER2/NEU Recombinant Antibody (A21).pdf

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Anti-Human CD340/ERBB2/HER2/NEU Recombinant Antibody (A21) (HY286307)

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