

| Catalog No. | HB157117 |
|---|---|
| Description |
Anti-Human CD49f/ITGA6 Antibody (P2D10), FITC [P2D10] (HB157117) is a mouse monoclonal antibody detecting ITGA6 in FCM. Suitable for Human.
Highlights
|
| Species reactivity | Human |
| Applications | FCM |
| Host species | Mouse |
| Isotype | IgG1, kappa |
| Clone ID | P2D10 |
| Conjugation | FITC |
| Clonality | Monoclonal |
| Target | CD49 antigen-like family member F, Integrin alpha-6, ITGA6, VLA-6, CD49f, Alpha6p |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | P23229 |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Background | Integrin alpha-6 (CD49f/ITGA6) is a ~126 kDa protein. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. 1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 2. Fujita, M. et al. (2012) The Journal of biological chemistry 287, 12491-500. PMID: 22351760 3. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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