Anti-Human CD54/ICAM1 Polyclonal Antibody (HY321014)

Name: Anti-Human CD54/ICAM1 Polyclonal Antibody
Brand: abinScience
SKU: HY321014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY321014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD54/ICAM1 (Gln28-Glu480).

Target

ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1

Purification

Purified by antigen affinity column.

Accession

P05362

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Intercellular adhesion molecule 1 (CD54/ICAM1) is a ~57 kDa protein. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1.

1. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451

2. Simmons, D. et al. (1988) Nature 331, 624-7. PMID: 3340213

3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629

4. Diamond, MS. et al. (1990) The Journal of cell biology 111, 3129-39. PMID: 1980124

5. van Buul, JD. et al. (2007) The Journal of cell biology 178, 1279-93. PMID: 17875742

6. Hayashi, T. et al. (2001) Digestion 63 Suppl 1, 87-92. PMID: 11173916

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human CD54/ICAM1 polyclonal antibody at 1ug/mL on recombinant Human CD54/ICAM1 (Catalog No. HY321012).

References

Datasheet