Anti-Human CD5L Recombinant Antibody (SAA1515) (HT064013)

Name: Anti-Human CD5L Recombinant Antibody (SAA1515)
Brand: abinScience
SKU: HT064013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT064013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1515

Clonality

Monoclonal

Target

CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, IgM-associated peptide, CT-2, hAIM, API6, SP-alpha, CD5L

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O43866

RRID

Anti-Human CD5L Antibody (SAA1515) (abinScience Cat# HT064013, RRID:AB_3727276)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

CD5 antigen-like (CD5L) is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).

1. Amézaga, N. et al. (2014) Journal of leukocyte biology 95, 509-20. PMID: 24295828

2. Sarrias, MR. et al. (2005) The Journal of biological chemistry 280, 35391-8. PMID: 16030018

3. Sanjurjo, L. et al. (2013) PloS one 8, e79670. PMID: 24223991

4. Martinez, VG. et al. (2014) Cellular & molecular immunology 11, 343-54. PMID: 24583716

5. Sanjurjo, L. et al. (2015) Autophagy 11, 487-502. PMID: 25713983

6. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD5L Antibody (SAA1515)

References

Datasheet

Anti-Human CD5L Recombinant Antibody (SAA1515).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CD5L Recombinant Antibody (SAA1515) (HT064013)

Overview

Images

References

Datasheet

SDS

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