Anti-Human CDCA7 Polyclonal Antibody (HP761014)

Name: Anti-Human CDCA7 Polyclonal Antibody
Brand: abinScience
SKU: HP761014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP761014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDCA7 (Thr246-Ala371).

Target

CDCA7, JPO1, Cell division cycle-associated protein 7, Protein JPO1

Purification

Purified by antigen affinity column.

Accession

Q9BWT1

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cell division cycle-associated protein 7 (CDCA7) is a ~42 kDa protein. Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator.

1. Prescott, JE. et al. (2001) The Journal of biological chemistry 276, 48276-84. PMID: 11598121

2. Osthus, RC. et al. (2005) Cancer research 65, 5620-7. PMID: 15994934

3. Gill, RM. et al. (2013) Molecular and cellular biology 33, 498-513. PMID: 23166294

4. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408

5. Wassing, IE. et al. (2024) Science advances 10, eadp5753. PMID: 39178260

6. Goto, Y. et al. (2006) Biochimica et biophysica acta 1759, 60-8. PMID: 16580749

Note

For research use only.

Images

References

Datasheet

Anti-Human CDCA7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CDCA7 Polyclonal Antibody (HP761014)

Overview

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References

Datasheet

SDS

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