Anti-Human CEP290 Polyclonal Antibody (HT321014)

Name: Anti-Human CEP290 Polyclonal Antibody
Brand: abinScience
SKU: HT321014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HT321014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CEP290 (Thr1289-Arg1416).

Target

Nephrocystin-6, KIAA0373, CEP290, Bardet-Biedl syndrome 14 protein, Tumor antigen se2-2, BBS14, NPHP6, Centrosomal protein of 290 kDa, Cancer/testis antigen 87, Cep290, CT87

Purification

Purified by antigen affinity column.

Accession

O15078

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Centrosomal protein of 290 kDa (CEP290) is a ~290 kDa protein. Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.

1. Tsang, WY. et al. (2008) Developmental cell 15, 187-97. PMID: 18694559

2. Kobayashi, T. et al. (2014) The Journal of cell biology 204, 215-29. PMID: 24421332

3. Frank, V. et al. (2008) Human mutation 29, 45-52. PMID: 17705300

4. Barbelanne, M. et al. (2015) Human molecular genetics 24, 2185-200. PMID: 25552655

5. Sayer, JA. et al. (2006) Nature genetics 38, 674-81. PMID: 16682973

Note

For research use only.

Images

References

Datasheet

Anti-Human CEP290 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-Human CEP290 Polyclonal Antibody (HT321014)

Overview

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References

Datasheet

SDS

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