Anti-Human CFH Recombinant Antibody (GT103) (HY505033)

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100ug
1mg

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Overview

Catalog No.	HY505033
Description	Anti-Human CFH Antibody (GT103) (HY505033) is a human monoclonal antibody detecting CFH. Suitable for Human.
Species reactivity	Homo sapiens (Human)
Applications	ELISA, IF, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG3, kappa
Clone ID	GT103
Clonality	Monoclonal
Target	CFH, Complement factor H, H factor 1, HF, HF1, HF2
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08603
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Complement factor H (CFH) is a ~139 kDa protein. Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. 1. Kajander, T. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2897-902. PMID: 21285368 2. Morgan, HP. et al. (2011) Nature structural & molecular biology 18, 463-70. PMID: 21317894 3. Blaum, BS. et al. (2015) Nature chemical biology 11, 77-82. PMID: 25402769 4. Wu, J. et al. (2009) Nature immunology 10, 728-33. PMID: 19503104 5. Kennedy, AT. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1239-48. PMID: 26700768 6. Hocking, HG. et al. (2008) The Journal of biological chemistry 283, 9475-87. PMID: 18252712 7. Simon, N. et al. (2013) Cell host & microbe 13, 29-41. PMID: 23332154 8. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 28671664 9. Losse, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 912-21. PMID: 20008295 10. DiScipio, RG. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 4057-66. PMID: 9558116
Note	For research use only