Anti-Human CFTR Monoclonal Antibody (1A509) (HY313025)

Name: Anti-Human CFTR Monoclonal Antibody (1A509)
Brand: abinScience
SKU: HY313025
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HY313025
Description	Anti-Human CFTR Monoclonal Antibody (1A509) [1A509] (HY313025) is a mouse monoclonal antibody detecting CFTR in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG
Clone ID	1A509
Immunogen	E. coli - derived recombinant human CFTR (Ile1203-Ser1426).
Target	Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, EC:5.6.1.6, cAMP-dependent chloride channel, CFTR
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P13569
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux. 1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428 2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060 3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016 4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463 5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745 6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365 7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899 8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866 9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471 10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051
Note	For research use only.

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Datasheet

Anti-Human CFTR Monoclonal Antibody (1A509).pdf

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Anti-Human CFTR Monoclonal Antibody (1A509) (HY313025)

Overview

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References

Datasheet

SDS