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Anti-Human CMKLR2 Polyclonal Antibody (HD623014)

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Overview
Catalog No.HD623014
Description
Anti-Human CMKLR2 Polyclonal Antibody (HD623014) is a rabbit polyclonal antibody detecting CMKLR2. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human CMKLR2 (Glu2-Ser41&Ser308-Gln355).
Target CMKLR2, Chemerin chemokine-like receptor 2, Chemerin-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1, GPR1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P46091
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Chemerin-like receptor 2 (CMKLR2) is a ~41 kDa protein. Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.

1. Barnea, G. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 64-9. PMID: 18165312
2. De Henau, O. et al. (2016) PloS one 11, e0164179. PMID: 27716822
Note For research use only
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Formula
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Anti-Human CMKLR2 Polyclonal Antibody

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