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Anti-Human CRBN Polyclonal Antibody (HP395014)

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Overview
Catalog No.HP395014
Description
Anti-Human CRBN Polyclonal Antibody (HP395014) is a rabbit polyclonal antibody detecting CRBN in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human CRBN (Met1-Leu442).
Target Protein cereblon, CRBN, AD-006
Purification Purified by antigen affinity column.
Accession Q96SW2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Protein cereblon (CRBN) is a ~50 kDa protein. Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.

1. Nguyen, TV. et al. (2016) Molecular cell 61, 809-20. PMID: 26990986
2. Lian, Q. et al. (2020) The protein journal 39, 411-421. PMID: 33009960
3. Ito, T. et al. (2010) Science (New York, N.Y.) 327, 1345-50. PMID: 20223979
4. Gandhi, AK. et al. (2014) British journal of haematology 164, 811-21. PMID: 24328678
5. Fischer, ES. et al. (2014) Nature 512, 49-53. PMID: 25043012
6. Chamberlain, PP. et al. (2014) Nature structural & molecular biology 21, 803-9. PMID: 25108355
7. Higgins, JJ. et al. (2008) Neurogenetics 9, 219-23. PMID: 18414909
8. Choi, TY. et al. (2018) The Journal of neuroscience : the official journal of the Society for Neuroscience 38, 3571-3583. PMID: 29530986
9. Kim, MJ. et al. (2019) Frontiers in immunology 10, 2203. PMID: 31620128
Note For research use only.
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Datasheet
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Formula
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Anti-Human CRBN Polyclonal Antibody

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