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Anti-Human DLG5 Polyclonal Antibody (HV023014)

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Overview
Catalog No.HV023014
Description
Anti-Human DLG5 Polyclonal Antibody (HV023014) is a rabbit polyclonal antibody detecting DLG5. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human DLG5 (Val1742-Asn1909).
Target DLG5, Discs large protein P-dlg, Disks large homolog 5, KIAA0583, PDLG, Placenta and prostate DLG
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8TDM6
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Disks large homolog 5 (DLG5) is a ~213 kDa protein. Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin.

1. Kwan, J. et al. (2016) Genes & development 30, 2696-2709. PMID: 28087714
2. Liu, J. et al. (2017) Scientific reports 7, 42125. PMID: 28169360
Note For research use only
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Datasheet
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Formula
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Formula
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human DLG5 Polyclonal Antibody

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