Human DLG5 Recombinant Protein (N-His) (HV023022)

Name: Human DLG5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV023022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HV023022
Description	Recombinant Human DLG5 Protein, N-His (HV023022) expressed in E. coli, spanning Val1742-Asn1909. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q8TDM6
Protein length	Val1742-Asn1909
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	21.66 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DLG5, Discs large protein P-dlg, Disks large homolog 5, KIAA0583, PDLG, Placenta and prostate DLG
Background	Disks large homolog 5 is a ~213 kDa protein. Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. 1. Kwan, J. et al. (2016) Genes & development 30, 2696-2709. PMID: 28087714 2. Liu, J. et al. (2017) Scientific reports 7, 42125. PMID: 28169360
Note	For research use only

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Datasheet

Human DLG5 Recombinant Protein (N-His).pdf

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Human DLG5 Recombinant Protein (N-His) (HV023022)

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