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Anti-Human EIF3E Polyclonal Antibody (HD106014)

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Overview
Catalog No.HD106014
Description
Anti-Human EIF3E Polyclonal Antibody (HD106014) is a rabbit polyclonal antibody detecting EIF3E. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human EIF3E (Met1-Tyr445).
Target EIF3E, EIF3S6, Eukaryotic translation initiation factor 3 subunit 6, Eukaryotic translation initiation factor 3 subunit E, INT6, Viral integration site protein INT-6 homolog, eIF-3 p48, eIF3e
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P60228
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Eukaryotic translation initiation factor 3 subunit E (EIF3E) is a ~52 kDa protein. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

1. Masutani, M. et al. (2007) The EMBO journal 26, 3373-83. PMID: 17581632
2. Lee, AS. et al. (2015) Nature 522, 111-4. PMID: 25849773
3. Lee, AS. et al. (2016) Nature 536, 96-9. PMID: 27462815
4. Morris, C. et al. (2007) EMBO reports 8, 596-602. PMID: 17468741
5. Buchsbaum, S. et al. (2007) Oncogene 26, 5132-44. PMID: 17310990
6. Chen, L. et al. (2007) The Journal of biological chemistry 282, 12707-16. PMID: 17324924
Note For research use only
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Formula
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Anti-Human EIF3E Polyclonal Antibody

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