Anti-Human EPHA2 Antibody (SAA2280) (HB738033)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

HB738033

Description

Anti-Human EPHA2 Antibody (SAA2280) [SAA2280] (HB738033) is a human monoclonal antibody detecting EPHA2 in ELISA, FCM. Suitable for Human.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Species reactivity

Human

Applications

ELISA, FCM

Host species

Human

Isotype

IgG1, kappa

Clone ID

SAA2280

Clonality

Monoclonal

Target

Ephrin type-A receptor 2, EC:2.7.10.1, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P29317

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ephrin type-A receptor 2 (EPHA2) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

Note

For research use only.

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