Anti-Human FXR1 Polyclonal Antibody (HW827014)

Name: Anti-Human FXR1 Polyclonal Antibody
Brand: abinScience
SKU: HW827014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW827014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human FXR1 (Met1-Ala173).

Target

Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1

Purification

Purified by antigen affinity column.

Accession

P51114

RRID

Anti-Human FXR1 Polyclonal Antibody (abinScience Cat# HW827014, RRID:AB_3730721)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

RNA-binding protein FXR1 is a ~69 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids. Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site.

1. Vasudevan, S. et al. (2007) Cell 128, 1105-18. PMID: 17382880

2. Say, E. et al. (2010) Molecular cell 38, 236-49. PMID: 20417602

3. Herman, AB. et al. (2018) Cell reports 24, 1176-1189. PMID: 30067974

4. George, J. et al. (2021) Cell reports 37, 109934. PMID: 34731628

5. Ling, H. et al. (2022) Oncogene 41, 4433-4445. PMID: 35989368

6. Datta, C. et al. (2022) Science advances 8, eabo1304. PMID: 36306353

9. Fischer-Kešo, R. et al. (2014) Molecular and cellular biology 34, 4244-56. PMID: 25225333

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human FXR1 polyclonal antibody at 1ug/mL on recombinant Human FXR1 (Catalog No. HW827012).

References

Datasheet

Anti-Human FXR1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human FXR1 Polyclonal Antibody (HW827014)

Overview

Images

References

Datasheet

SDS

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