Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Name: Anti-Human GFR alpha-like Recombinant Antibody (SAA1999)
Brand: abinScience
SKU: HS720013
Price: 110 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS720013

Species reactivity

Human

Applications

ELISA, WB

Host species

Human

Isotype

IgG1

Clone ID

SAA1999

Clonality

Monoclonal

Target

C6orf144, GDNF family receptor alpha-like, GFRAL

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6UXV0

RRID

Anti-Human GFRAL Antibody (SAA1999) (abinScience Cat# HS720013, RRID:AB_3727911)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

7. Li, J. et al. (2019) eLife 8. PMID: 31535977

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human GFRAL Antibody (SAA1999).

References

Datasheet

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

Overview

Images

References

Datasheet

SDS

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