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Anti-Human GPR37L1 Polyclonal Antibody (HD416014)

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Overview
Catalog No.HD416014
Description
Anti-Human GPR37L1 Polyclonal Antibody (HD416014) is a rabbit polyclonal antibody detecting GPR37L1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human GPR37L1 (Ala26-Met134).
Target ETBR-LP-2, ETBRLP2, Endothelin B receptor-like protein 2, G-protein coupled receptor 37-like 1, GPR37L1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O60883
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

G-protein coupled receptor 37-like 1 (GPR37L1) is a ~52 kDa protein. G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway.

1. Coleman, JL. et al. (2016) Science signaling 9, ra36. PMID: 27072655
2. Meyer, RC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 9529-34. PMID: 23690594
3. Giddens, MM. et al. (2017) Neurobiology of disease 106, 181-190. PMID: 28688853
Note For research use only
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Formula
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Anti-Human GPR37L1 Polyclonal Antibody

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