Anti-Human HCN4 Recombinant Antibody (N114/10.1) (HY088013)

Name: Anti-Human HCN4 Recombinant Antibody (N114/10.1)
Brand: abinScience
SKU: HY088013
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY088013

Species reactivity

Human

Applications

IF, IHC, WB

Host species

Mouse

Isotype

IgG1

Clone ID

N114/10.1

Clonality

Monoclonal

Target

HCN4, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y3Q4

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) is a ~129 kDa protein. Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (Probable). Contributes to the native pacemaker currents in neurons (Ih) (Probable). May mediate responses to sour stimuli.

1. Ludwig, A. et al. (1999) The EMBO journal 18, 2323-9. PMID: 10228147

2. Seifert, R. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 9391-6. PMID: 10430953

3. Xu, X. et al. (2010) The Journal of biological chemistry 285, 37082-91. PMID: 20829353

4. Milanesi, R. et al. (2006) The New England journal of medicine 354, 151-7. PMID: 16407510

5. Ueda, K. et al. (2009) Journal of human genetics 54, 115-21. PMID: 19165230

Note

For research use only.

Images

Bioactivity

SEC-HPLC detection for Anti-Human HCN4 Antibody (N114/10.1).
SDS-PAGE

SDS-PAGE for Anti-Human HCN4 Antibody (N114/10.1).

References

Datasheet

Anti-Human HCN4 Recombinant Antibody (N114/10.1).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human HCN4 Recombinant Antibody (N114/10.1) (HY088013)

Overview

Images

References

Datasheet

SDS

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