

| Catalog No. | HD507014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human HCRTR2 Polyclonal Antibody (HD507014) is a rabbit polyclonal antibody detecting HCRTR2. Suitable for Human.
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human HCRTR2 (Ser2-Glu54&Glu192-Met222&Leu367-Trp444). | ||||||||
| Target | HCRTR2, Hypocretin receptor type 2, ORXR2, OX2R, OXR2, Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O43614 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Background | Orexin receptor type 2 (HCRTR2) is a ~50 kDa protein. G-protein coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis. 1. Yin, J. et al. (2016) Nature structural & molecular biology 23, 293-9. PMID: 26950369 2. Hong, C. et al. (2021) Nature communications 12, 815. PMID: 33547286 3. Yin, J. et al. (2022) Nature communications 13, 2902. PMID: 35614071 4. Sakurai, T. et al. (1998) Cell 92, 573-85. PMID: 9491897 | ||||||||
| Note | For research use only |
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