Human HCRTR2 Recombinant Protein (N-His-KSI) (HD507012)

Name: Human HCRTR2 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD507012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD507012
Description	Recombinant Human HCRTR2 Protein, N-His-KSI (HD507012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O43614
Protein length	Ser2-Glu54&Glu192-Met222&Leu367-Trp444
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HCRTR2, Hypocretin receptor type 2, ORXR2, OX2R, OXR2, Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R
Background	Orexin receptor type 2 is a ~50 kDa protein. G-protein coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis. 1. Yin, J. et al. (2016) Nature structural & molecular biology 23, 293-9. PMID: 26950369 2. Hong, C. et al. (2021) Nature communications 12, 815. PMID: 33547286 3. Yin, J. et al. (2022) Nature communications 13, 2902. PMID: 35614071 4. Sakurai, T. et al. (1998) Cell 92, 573-85. PMID: 9491897
Note	For research use only

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Datasheet

Human HCRTR2 Recombinant Protein (N-His-KSI).pdf

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Human HCRTR2 Recombinant Protein (N-His-KSI) (HD507012)

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