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Anti-Human HIPK2 Polyclonal Antibody (HC246014)

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Overview
Catalog No.HC246014
Description
Anti-Human HIPK2 Polyclonal Antibody (HC246014) is a rabbit polyclonal antibody detecting HIPK2. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human HIPK2 (Gln188-Arg553).
Target EC:2.7.11.1, HIPK2, Homeodomain-interacting protein kinase 2, hHIPk2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9H2X6
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Homeodomain-interacting protein kinase 2 (HIPK2) is a ~130 kDa protein. Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex.

1. Liebl, MC. et al. (2021) Nucleic acids research 49, 2759-2776. PMID: 33591310
Note For research use only
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Formula
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Anti-Human HIPK2 Polyclonal Antibody

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