Human HIPK2 Recombinant Protein (N-His) (HC246012)

Name: Human HIPK2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC246012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC246012
Description	Recombinant Human HIPK2 Protein, N-His (HC246012) expressed in E. coli, spanning Gln188-Arg553. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9H2X6
Protein length	Gln188-Arg553
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	44.45 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.11.1, HIPK2, Homeodomain-interacting protein kinase 2, hHIPk2
Background	Homeodomain-interacting protein kinase 2 is a ~130 kDa protein. Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. 1. Liebl, MC. et al. (2021) Nucleic acids research 49, 2759-2776. PMID: 33591310
Note	For research use only

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Datasheet

Human HIPK2 Recombinant Protein (N-His).pdf

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Human HIPK2 Recombinant Protein (N-His) (HC246012)

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