Anti-Human HMGB1 Monoclonal Antibody (1A068) (HY200025)

Name: Anti-Human HMGB1 Monoclonal Antibody (1A068)
Brand: abinScience
SKU: HY200025
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HY200025
Description	Anti-Human HMGB1 Monoclonal Antibody (1A068) [1A068] (HY200025) is a mouse monoclonal antibody detecting HMGB1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone ID	1A068
Immunogen	Mammalian cells - derived recombinant Human HMGB1 (Met1-Glu215).
Target	High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1,
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P09429
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. 1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444 2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237 3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181 4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148 5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706 6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764 7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472 8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669 9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101
Note	For research use only.

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SDS-PAGE for Anti-Human HMGB1 Monoclonal Antibody (1A068)

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Datasheet

Anti-Human HMGB1 Monoclonal Antibody (1A068).pdf

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Anti-Human HMGB1 Monoclonal Antibody (1A068) (HY200025)

Overview

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References

Datasheet

SDS