Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397) (HV454107)

Name: Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397)
Brand: abinScience
SKU: HV454107
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HV454107
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0397
Clonality	Monoclonal
Target	IL1F6, IL-1 epsilon, IL1E, IL36A, Interleukin-1 family member 6, FIL1 epsilon, FIL1E, IL-1F6, Interleukin-36 alpha, Interleukin-1 epsilon
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9UHA7
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-36 alpha (IL36A/IL-1F6) is a ~17 kDa protein. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6.
Note	For research use only.

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SDS-PAGE for Anti-Human IL36A/IL-1F6 Antibody (SAA0397)

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Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397).pdf

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Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397) (HV454107)

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Datasheet

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