Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397), PE (HV454127)

Name: Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397), PE
Brand: abinScience
SKU: HV454127
Price: 256 USD
Availability: InStock

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Overview

Catalog No.	HV454127
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0397
Conjugation	PE
Clonality	Monoclonal
Target	IL1F6, IL-1 epsilon, IL1E, IL36A, Interleukin-1 family member 6, FIL1 epsilon, FIL1E, IL-1F6, Interleukin-36 alpha, Interleukin-1 epsilon
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Accession	Q9UHA7
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Interleukin-36 alpha (IL36A/IL-1F6) is a ~17 kDa protein. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397), PE.pdf

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Anti-Human IL36A/IL-1F6 Recombinant Antibody (SAA0397), PE (HV454127)

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