Anti-Human ING4 Polyclonal Antibody (HP148014)

Name: Anti-Human ING4 Polyclonal Antibody
Brand: abinScience
SKU: HP148014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP148014

Description

Anti-Human ING4 Polyclonal Antibody (HP148014) is a rabbit polyclonal antibody detecting ING4 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ING4 (Met1-Lys127).

Target

ING4, Inhibitor of growth protein 4, p29ING4

Purification

Purified by antigen affinity column.

Accession

Q9UNL4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Inhibitor of growth protein 4 (ING4) is a ~28 kDa protein. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC.

1. Doyon, Y. et al. (2006) Molecular cell 21, 51-64. PMID: 16387653

2. Zhang, X. et al. (2004) FEBS letters 570, 7-12. PMID: 15251430

3. Kim, S. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16251-6. PMID: 15528276

4. Garkavtsev, I. et al. (2004) Nature 428, 328-32. PMID: 15029197

5. Ozer, A. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 7481-6. PMID: 15897452

Note

For research use only.

Images

References

Datasheet

Anti-Human ING4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ING4 Polyclonal Antibody (HP148014)

Overview

Images

References

Datasheet

SDS

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