Anti-Human ITGB7 Polyclonal Antibody (HB878014)

Name: Anti-Human ITGB7 Polyclonal Antibody
Brand: abinScience
SKU: HB878014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB878014

Description

Anti-Human ITGB7 Polyclonal Antibody (HB878014) is a rabbit polyclonal antibody detecting ITGB7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ITGB7 (Tyr150-Thr392).

Target

Integrin beta-7, Gut homing receptor beta subunit, ITGB7

Purification

Purified by antigen affinity column.

Accession

P26010

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Integrin beta-7 (ITGB7) is a ~86 kDa protein. Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable).

1. Higgins, JM. et al. (2000) The Journal of biological chemistry 275, 25652-64. PMID: 10837471

2. Chen, J. et al. (2003) Nature structural biology 10, 995-1001. PMID: 14608374

Note

For research use only.

Images

References

Datasheet