Anti-Human JIP-3/MAPK8IP3 Polyclonal Antibody (HC769014)

Name: Anti-Human JIP-3/MAPK8IP3 Polyclonal Antibody
Brand: abinScience
SKU: HC769014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HC769014

Description

Anti-Human JIP-3/MAPK8IP3 Polyclonal Antibody (HC769014) is a rabbit polyclonal antibody detecting MAPK8IP3. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human JIP-3/MAPK8IP3 (Trp972-Glu1336).

Target

C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JIP3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, KIAA1066, MAPK8IP3, Mitogen-activated protein kinase 8-interacting protein 3

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9UPT6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3/MAPK8IP3) is a ~147 kDa protein. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration.

1. Matsuura, H. et al. (2002) The Journal of biological chemistry 277, 40703-9. PMID: 12189133

2. Huang, SH. et al. (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 10602-14. PMID: 21775604

Note

For research use only

Images

References

Datasheet

Anti-Human JIP-3/MAPK8IP3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human JIP-3/MAPK8IP3 Polyclonal Antibody (HC769014)

Overview

Images

References

Datasheet

SDS

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