Human JIP-3/MAPK8IP3 Recombinant Protein (N-His) (HC769012)

Name: Human JIP-3/MAPK8IP3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC769012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC769012
Description	Recombinant Human JIP-3/MAPK8IP3 Protein, N-His (HC769012) expressed in E. coli, spanning Trp972-Glu1336. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9UPT6
Protein length	Trp972-Glu1336
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	42.43 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C-Jun-amino-terminal kinase-interacting protein 3, JIP-3, JIP3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, KIAA1066, MAPK8IP3, Mitogen-activated protein kinase 8-interacting protein 3
Background	C-Jun-amino-terminal kinase-interacting protein 3 is a ~147 kDa protein. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. 1. Matsuura, H. et al. (2002) The Journal of biological chemistry 277, 40703-9. PMID: 12189133 2. Huang, SH. et al. (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 10602-14. PMID: 21775604
Note	For research use only

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Datasheet

Human JIP-3/MAPK8IP3 Recombinant Protein (N-His).pdf

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Human JIP-3/MAPK8IP3 Recombinant Protein (N-His) (HC769012)

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