Anti-Human JMJD6 IP Recombinant Antibody (SAA0203) (HP634013)

Name: Anti-Human JMJD6 IP Recombinant Antibody (SAA0203)
Brand: abinScience
SKU: HP634013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP634013

Species reactivity

Human

Applications

ELISA, IF, IP

Host species

Mouse

Isotype

IgG1

Clone ID

SAA0203

Clonality

Monoclonal

Target

Histone arginine demethylase JMJD6, Phosphatidylserine receptor, JmjC domain-containing protein 6, JMJD6, PTDSR, PSR, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Jumonji domain-containing protein 6, Protein PTDSR, Peptide-lysine 5-dioxygenase JMJD6, Lysyl-hydroxylase JMJD6, KIAA0585

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6NYC1

RRID

Anti-Human JMJD6 IP Antibody (SAA0203) (abinScience Cat# HP634013, RRID:AB_3729737)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is a ~46 kDa protein. Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting.

1. Chang, B. et al. (2007) Science (New York, N.Y.) 318, 444-7. PMID: 17947579

2. Mantri, M. et al. (2010) Journal of molecular biology 401, 211-22. PMID: 20684070

3. Hahn, P. et al. (2010) PloS one 5, e13769. PMID: 21060799

4. Han, G. et al. (2012) Journal of cellular biochemistry 113, 1663-70. PMID: 22189873

5. Poulard, C. et al. (2014) PloS one 9, e87982. PMID: 24498420

6. Webby, CJ. et al. (2009) Science (New York, N.Y.) 325, 90-3. PMID: 19574390

7. Hong, X. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 14568-72. PMID: 20679243

8. Konuma, T. et al. (2017) Scientific reports 7, 16272. PMID: 29176719

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human JMJD6 IP Antibody (SAA0203)

References

Datasheet

Anti-Human JMJD6 IP Recombinant Antibody (SAA0203).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human JMJD6 IP Recombinant Antibody (SAA0203) (HP634013)

Overview

Images

References

Datasheet

SDS

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