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Anti-Human LACTB Polyclonal Antibody (HD571014)

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Overview
Catalog No.HD571014
Description
Anti-Human LACTB Polyclonal Antibody (HD571014) is a rabbit polyclonal antibody detecting LACTB. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human LACTB (Cys100-Ser256).
Target EC:3.4.-.-, LACTB, MRPL56, Serine beta-lactamase-like protein LACTB, mitochondrial
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P83111
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Serine beta-lactamase-like protein LACTB, mitochondrial is a ~60 kDa protein. Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.

1. Keckesova, Z. et al. (2017) Nature 543, 681-686. PMID: 28329758
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human LACTB Polyclonal Antibody

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