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Anti-Human LDLRAD4 Polyclonal Antibody (HD518014)

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Overview
Catalog No.HD518014
Description
Anti-Human LDLRAD4 Polyclonal Antibody (HD518014) is a rabbit polyclonal antibody detecting LDLRAD4. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human LDLRAD4 (Leu86-Val306).
Target C18orf1, LDLRAD4, Low-density lipoprotein receptor class A domain-containing protein 4
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O15165
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4) is a ~33 kDa protein. Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Note For research use only
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Anti-Human LDLRAD4 Polyclonal Antibody

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