Anti-Human LGR5/GPR49 Recombinant Antibody (SAA0507), APC (HF614137)

Name: Anti-Human LGR5/GPR49 Recombinant Antibody (SAA0507), APC
Brand: abinScience
SKU: HF614137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HF614137
Species reactivity	Human
Applications	FCM, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0507
Conjugation	APC
Clonality	Monoclonal
Target	G-protein coupled receptor 49, G-protein coupled receptor HG38, LGR5, GPR67, GPR49, G-protein coupled receptor 67, Leucine-rich repeat-containing G-protein coupled receptor 5
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Accession	O75473
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5/GPR49) is a ~99 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.