Anti-Human Lgr5/GPR49 Reference Antibody (18G7H6A3, RUO) (HF614026)

Name: Anti-Human Lgr5/GPR49 Reference Antibody (18G7H6A3, RUO)
Brand: abinScience
SKU: HF614026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HF614026
Description	Anti-Human LGR5/GPR49 Antibody (18G7H6A3) (HF614026) is a research-grade recombinant antibody targeting G-protein coupled receptor 49. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1
Clone ID	18G7H6A3
Expression system	Mammalian cells
Clonality	Monoclonal
Target	G-protein coupled receptor 49, G-protein coupled receptor HG38, LGR5, GPR67, GPR49, G-protein coupled receptor 67, Leucine-rich repeat-containing G-protein coupled receptor 5
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O75473
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5/GPR49) is a ~99 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human LGR5/GPR49 Antibody (18G7H6A3)

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Anti-Human Lgr5/GPR49 Reference Antibody (18G7H6A3, RUO).pdf

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Anti-Human Lgr5/GPR49 Reference Antibody (18G7H6A3, RUO) (HF614026)

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