Anti-Human MAGEA6 Polyclonal Antibody (HW297014)

Name: Anti-Human MAGEA6 Polyclonal Antibody
Brand: abinScience
SKU: HW297014
Price: 96 USD
Availability: InStock

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SDS

Overview

Catalog No.

HW297014

Description

Anti-Human MAGEA6 Polyclonal Antibody (HW297014) is a rabbit polyclonal antibody detecting MAGEA6 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MAGEA6 (Ser96-Glu314).

Target

MAGEA6, Cancer/testis antigen 1.6, MAGE6, MAGE3B antigen, MAGE-6 antigen, CT1.6, Melanoma-associated antigen 6

Purification

Purified by antigen affinity column.

Accession

P43360

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Melanoma-associated antigen 6 (MAGEA6) is a ~34 kDa protein. Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

1. Yang, B. et al. (2007) Cancer research 67, 9954-62. PMID: 17942928

2. Doyle, JM. et al. (2010) Molecular cell 39, 963-74. PMID: 20864041

3. Ravichandran, R. et al. (2019) EMBO reports 20, e47352. PMID: 31267705

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-MAGEA6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse testis lysate

References

Datasheet

Anti-Human MAGEA6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human MAGEA6 Polyclonal Antibody (HW297014)

Overview

Images

References

Datasheet

SDS

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