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Anti-Human MC3R Polyclonal Antibody (HC053014)

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Overview
Catalog No.HC053014
Description
Anti-Human MC3R Polyclonal Antibody (HC053014) is a rabbit polyclonal antibody detecting Melanocortin receptor 3; MC3-R; MC3R in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant human MC3R (Asn2-Gln37&Val101-Asn118&Arg302-Gly323).
Target Melanocortin receptor 3; MC3-R; MC3R
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P41968
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Melanocortin receptor 3 (MC3R) is a ~36 kDa protein. G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production.

1. Feng, W. et al. (2023) Cell discovery 9, 81. PMID: 37524700
2. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 8246-50. PMID: 8463333
3. Mencarelli, M. et al. (2008) European journal of human genetics : EJHG 16, 581-6. PMID: 18231126
4. Ollmann, MM. et al. (1997) Science (New York, N.Y.) 278, 135-8. PMID: 9311920
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human MC3R Polyclonal Antibody

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