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Anti-Human PMPCB Polyclonal Antibody (HC189014)

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Overview
Catalog No.HC189014
Description
Anti-Human PMPCB Polyclonal Antibody (HC189014) is a rabbit polyclonal antibody detecting PMPCB. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PMPCB (Arg59-Asp489).
Target Beta-MPP, EC:3.4.24.64, MPPB, Mitochondrial-processing peptidase subunit beta, P-52, PMPCB
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O75439
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Mitochondrial-processing peptidase subunit beta (PMPCB) is a ~54 kDa protein. Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.

1. Vögtle, FN. et al. (2018) American journal of human genetics 102, 557-573. PMID: 29576218
2. Greene, AW. et al. (2012) EMBO reports 13, 378-85. PMID: 22354088
Note For research use only
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Formula
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Anti-Human PMPCB Polyclonal Antibody

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