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Anti-Human POLD4 Polyclonal Antibody (HD558014)

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Overview
Catalog No.HD558014
Description
Anti-Human POLD4 Polyclonal Antibody (HD558014) is a rabbit polyclonal antibody detecting POLD4. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human POLD4 (Glu45-Leu107).
Target DNA polymerase delta subunit 4, DNA polymerase delta subunit p12, POLD4, POLDS
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9HCU8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

DNA polymerase delta subunit 4 (POLD4) is a ~12 kDa protein. As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites.

1. Li, H. et al. (2006) The Journal of biological chemistry 281, 14748-55. PMID: 16510448
2. Meng, X. et al. (2009) Nucleic acids research 37, 647-57. PMID: 19074196
3. Meng, X. et al. (2010) Biochemistry 49, 3545-54. PMID: 20334433
4. Lin, SH. et al. (2013) DNA repair 12, 922-35. PMID: 24035200
5. Costantino, L. et al. (2014) Science (New York, N.Y.) 343, 88-91. PMID: 24310611
6. Terai, K. et al. (2013) The Journal of biological chemistry 288, 30509-30514. PMID: 24022480
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-Human POLD4 Polyclonal Antibody

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