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Anti-Human RB1CC1 Polyclonal Antibody (HP312014)

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Overview
Catalog No.HP312014
Description
Anti-Human RB1CC1 Polyclonal Antibody (HP312014) is a rabbit polyclonal antibody detecting RB1CC1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human RB1CC1 (Glu1447-Val1594).
Target FAK family kinase-interacting protein of 200 kDa, RB1CC1, FIP200, RBICC, RB1-inducible coiled-coil protein 1, KIAA0203
Purification Purified by antigen affinity column.
Accession Q8TDY2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

RB1-inducible coiled-coil protein 1 (RB1CC1) is a ~183 kDa protein. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways.

1. Morselli, E. et al. (2011) Cell cycle (Georgetown, Tex.) 10, 2763-9. PMID: 21775823
2. Nishimura, T. et al. (2013) EMBO reports 14, 284-91. PMID: 23392225
3. Ueda, H. et al. (2000) The Journal of cell biology 149, 423-30. PMID: 10769033
4. Abbi, S. et al. (2002) Molecular biology of the cell 13, 3178-91. PMID: 12221124
5. Chano, T. et al. (2002) Gene 291, 29-34. PMID: 12095676
6. Kontani, K. et al. (2003) International journal of molecular medicine 12, 767-9. PMID: 14533007
7. Chano, T. et al. (2002) The American journal of pathology 161, 359-64. PMID: 12163359
Note For research use only.
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Datasheet
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Formula
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V₁ (Stock Vol.)
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Anti-Human RB1CC1 Polyclonal Antibody

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