

| Catalog No. | HA495014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human RDH12 Polyclonal Antibody (HA495014) is a rabbit polyclonal antibody detecting RDH12 in ELISA, IHC, WB. Suitable for Bovine, Mus musculus, and Human.
Highlights
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human RDH12 (Thr33-Glu316). | ||||||||
| Target | RDH12 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q96NR8 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Alternate Names | Retinol dehydrogenase 12, 1.1.1.300, All-trans and 9-cis retinol dehydrogenase, Short chain dehydrogenase/reductase family 7C member 2, RDH12, SDR7C2 | ||||||||
| Background | Retinol dehydrogenase 12 (RDH12) is a ~35 kDa protein. Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. 1. Haeseleer, F. et al. (2002) The Journal of biological chemistry 277, 45537-45546. PMID: 12226107 2. Belyaeva, OV. et al. (2005) Biochemistry 44, 7035-47. PMID: 15865448 3. Marchette, LD. et al. (2010) Free radical biology & medicine 48, 16-25. PMID: 19686838 | ||||||||
| Note | For research use only. |
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